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Marcel Verheij Selected Research

edelfosine

5/2014Combining anti-tumor alkyl-phospholipid analogs and radiotherapy: rationale and clinical outlook.
11/2011Phosphoinositide phosphatase SHIP-1 regulates apoptosis induced by edelfosine, Fas ligation and DNA damage in mouse lymphoma cells.
12/2009Fas/CD95 down-regulation in lymphoma cells through acquired alkyllysophospholipid resistance: partial role of associated sphingomyelin deficiency.
11/2007Lipid rafts and metabolic energy differentially determine uptake of anti-cancer alkylphospholipids in lymphoma versus carcinoma cells.
8/2007A new class of anticancer alkylphospholipids uses lipid rafts as membrane gateways to induce apoptosis in lymphoma cells.
1/2007Resistance to alkyl-lysophospholipid-induced apoptosis due to downregulated sphingomyelin synthase 1 expression with consequent sphingomyelin- and cholesterol-deficiency in lipid rafts.
2/2003Anti-cancer alkyl-lysophospholipids inhibit the phosphatidylinositol 3-kinase-Akt/PKB survival pathway.

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Marcel Verheij Research Topics

Disease

67Neoplasms (Cancer)
06/2022 - 02/2003
37Stomach Neoplasms (Stomach Cancer)
06/2022 - 03/2007
16Squamous Cell Carcinoma of Head and Neck
01/2020 - 08/2006
9Lymphoma (Lymphomas)
03/2013 - 09/2003
8Carcinoma (Carcinomatosis)
03/2019 - 02/2003
8Head and Neck Neoplasms (Head and Neck Cancer)
03/2019 - 03/2008
7Breast Neoplasms (Breast Cancer)
04/2020 - 04/2011
6Neoplasm Metastasis (Metastasis)
11/2021 - 10/2017
6Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2021 - 06/2007
6Squamous Cell Carcinoma (Epidermoid Carcinoma)
01/2018 - 08/2005
5Hypoxia (Hypoxemia)
04/2020 - 12/2015
4Deglutition Disorders (Dysphagia)
01/2022 - 08/2006
4Adenocarcinoma
09/2018 - 12/2007
4Lung Neoplasms (Lung Cancer)
01/2018 - 08/2006
3Pneumonia (Pneumonitis)
01/2020 - 08/2006
2Rectal Neoplasms (Rectal Cancer)
09/2021 - 01/2015
2Sarcoma (Soft Tissue Sarcoma)
08/2020 - 01/2019
2Hypersensitivity (Allergy)
11/2019 - 04/2018
2Weight Loss (Weight Reduction)
01/2016 - 05/2013
2Prostatic Neoplasms (Prostate Cancer)
02/2015 - 02/2014
2Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular)
08/2007 - 12/2003
1Diarrhea
06/2022
1Liver Neoplasms (Liver Cancer)
11/2021
1Mucinous Adenocarcinoma (Mucinous Carcinoma)
09/2021
1Exanthema (Rash)
01/2020
1Mesothelioma
01/2020
1Ovarian Neoplasms (Ovarian Cancer)
01/2020
1Thrombosis (Thrombus)
01/2020
1Venous Thromboembolism
01/2020
1Lymphatic Metastasis
05/2019
1Wounds and Injuries (Trauma)
01/2019

Drug/Important Bio-Agent (IBA)

16Cisplatin (Platino)FDA LinkGeneric
06/2022 - 08/2006
12Pharmaceutical PreparationsIBA
08/2020 - 08/2005
7DNA (Deoxyribonucleic Acid)IBA
09/2020 - 01/2018
7Capecitabine (Xeloda)FDA Link
01/2020 - 12/2007
7perifosineIBA
05/2014 - 02/2003
7edelfosineIBA
05/2014 - 02/2003
6olaparibIBA
01/2021 - 09/2015
6Liposomes (Liposome)IBA
08/2020 - 11/2005
6LipidsIBA
08/2015 - 08/2007
5SphingolipidsIBA
08/2020 - 01/2011
5PlatinumIBA
01/2020 - 09/2004
4Proteins (Proteins, Gene)FDA Link
01/2020 - 10/2009
4Doxorubicin (Adriamycin)FDA LinkGeneric
08/2015 - 11/2005
4LysophospholipidsIBA
11/2011 - 02/2003
3Oxaliplatin (Eloxatin)FDA LinkGeneric
06/2022 - 09/2018
3Poly(ADP-ribose) Polymerase InhibitorsIBA
01/2021 - 09/2015
3Biomarkers (Surrogate Marker)IBA
01/2020 - 09/2008
3Epirubicin (Ellence)FDA LinkGeneric
01/2020 - 08/2011
3Cetuximab (Erbitux)FDA Link
01/2020 - 01/2014
3Biological ProductsIBA
01/2019 - 08/2007
3Annexin A5IBA
04/2011 - 06/2007
2Tumor Biomarkers (Tumor Markers)IBA
03/2022 - 01/2019
2AntibodiesIBA
01/2021 - 01/2016
2Cell-Free Nucleic AcidsIBA
01/2020 - 01/2019
2RNA (Ribonucleic Acid)IBA
01/2020 - 01/2019
2Mitomycin (Mitomycin-C)FDA LinkGeneric
11/2019 - 04/2018
2Docetaxel (Taxotere)FDA Link
09/2018 - 04/2011
2Carboplatin (JM8)FDA LinkGeneric
09/2018 - 08/2014
2Paclitaxel (Taxol)FDA LinkGeneric
09/2018 - 08/2014
2Mitoxantrone (Novantrone)FDA LinkGeneric
08/2015 - 04/2015
2miltefosine (Impavido)IBA
05/2014 - 02/2003
2erucylphosphocholineIBA
05/2014 - 08/2007
2Phospholipids (Phosphatides)FDA LinkGeneric
05/2014 - 04/2007
2Therapeutic UsesIBA
03/2009 - 09/2008
2Phosphatidylcholines (Phosphatidylcholine)IBA
01/2008 - 09/2003
2Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
01/2008 - 02/2003
1Yttrium-90IBA
11/2021
1Holmium-166IBA
11/2021
1SirtuinsIBA
11/2021
1AntigensIBA
01/2021
1Neoplasm Antigens (Tumor Antigens)IBA
01/2021
1EnzymesIBA
01/2020
1vinyltriethoxysilane (VTES)IBA
01/2020
1avelumabIBA
01/2020
1Prednisone (Sone)FDA LinkGeneric
01/2020
1SteroidsIBA
01/2020
1tyramine-deoxysorbitolIBA
05/2019
1Biological FactorsIBA
01/2019

Therapy/Procedure

54Radiotherapy
11/2021 - 12/2003
28Chemoradiotherapy
11/2021 - 03/2007
24Drug Therapy (Chemotherapy)
06/2022 - 09/2004
19Therapeutics
01/2022 - 08/2006
6Lymph Node Excision (Lymph Node Dissection)
12/2018 - 05/2010
4Neoadjuvant Therapy
01/2022 - 01/2019
4Gastrectomy
12/2019 - 05/2012
4Adjuvant Chemoradiotherapy
09/2018 - 01/2012
2Induction Chemotherapy
12/2019 - 12/2018
2Particle Accelerators
11/2019 - 01/2017
2Radioimmunotherapy
01/2019 - 08/2014
2Immunotherapy
01/2019 - 01/2016
2Adjuvant Chemotherapy
09/2018 - 08/2011
2Aftercare (After-Treatment)
04/2011 - 03/2006
1Ablation Techniques
01/2021
1Nutritional Support (Artificial Feeding)
01/2020
1Combined Modality Therapy
01/2019
1Enteral Nutrition (Feeding, Tube)
01/2019
1Intensity-Modulated Radiotherapy (Radiotherapy, Intensity Modulated)
01/2019
1Patient Readmission
01/2019
1Immunomodulation
01/2019